Catapres 100mcg (Clonidine) - Generic

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ARKAMIN is the international generic and equivalent of Catapres

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Catapres 100mcg  (Clonidine) - Generic

What is Generic Catapres (Clonidine)?
Generic Catapres (Clonidine) lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels to relax and your heart to beat more slowly and easily.Generic Catapres (Clonidine) is used to treat hypertension (high blood pressure). It is sometimes used together with other blood pressure medications.Although not approved by the FDA for these purposes, Generic Catapres (Clonidine) has also been used to relieve alcohol withdrawal, as an aid in methadone and opiate detoxification, as an aid in quitting smoking, to treat diabetic diarrhea, to treat Tourette's Syndrome. Generic Catapres (Clonidine) has also been used to reduce menopausal flushing, to treat postherpetic neuralgia, to treat ulcerative colitis, and to diagnose pheochromocytoma.Generic Catapres (Clonidine) may also be used for other purposes not listed in this medication guide.


Important information about Generic Catapres (Clonidine)
Before you take Generic Catapres (Clonidine), tell your doctor if you have heart disease or severe coronary artery disease, a heart rhythm disorder, a history of heart attack or stroke, kidney disease, or if you have ever had an allergic reaction to a Generic Catapres (Clonidine) transdermal skin patch (Catapres TTS).Do not stop taking this medication suddenly without first talking to your doctor. Stopping this medication suddenly can cause nervousness, agitation, headache, tremors, severe high blood pressure, or life-threatening symptoms. Talk with your doctor about how to avoid withdrawal symptoms when you stop taking Generic Catapres (Clonidine). Avoid drinking alcohol. It can increase some of the side effects of Generic Catapres (Clonidine).Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.Generic Catapres (Clonidine) can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.


Before taking Generic Catapres (Clonidine)
You should not take this medication if you are allergic to Generic Catapres (Clonidine).If you have certain conditions, you may need a dose adjustment or special tests to safely use Generic Catapres (Clonidine). 


Before you take Generic Catapres (Clonidine), tell your doctor if you have:
heart disease or severe coronary artery disease;a heart rhythm disorder;a history of heart attack or stroke;kidney disease; or if you have ever had an allergic reaction to a Generic Catapres (Clonidine) transdermal skin patch (Catapres TTS).


How should I take Generic Catapres (Clonidine)?
Take Generic Catapres (Clonidine) exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the instructions on your prescription label.Your doctor may occasionally change your dose to make sure you get the best results from Generic Catapres (Clonidine).Generic Catapres (Clonidine) is usually taken in the morning and at bedtime. Follow your doctor's instructions.If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Generic Catapres (Clonidine). You may need to stop using the medicine for a short time. Do not stop taking this medication suddenly without first talking to your doctor. Stopping this medication suddenly can cause nervousness, agitation, headache, tremors, severe high blood pressure, or life-threatening symptoms. Talk with your doctor about how to avoid withdrawal symptoms when you stop taking Generic Catapres (Clonidine).Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.


Store Generic Catapres (Clonidine) at room temperature away from moisture, heat, and light. 


What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.


What happens if I overdose?
Seek emergency medical attention if you think you have used too much Generic Catapres (Clonidine).Overdose symptoms may include high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath) followed by low blood pressure (feeling light-headed, fainting), drowsiness, cold feeling, slow heart rate, shallow breathing, weakness, fainting, or pinpoint pupils.


What should I avoid while taking Generic Catapres (Clonidine)?
Avoid drinking alcohol. It can increase some of the side effects of Generic Catapres (Clonidine). Generic Catapres (Clonidine) can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Side effects of Generic Catapres (Clonidine) Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:fast or pounding heartbeats;a very slow heart rate (fewer than 60 beats per minute);feeling short of breath, even with mild exertion;swelling, rapid weight gain;confusion, hallucinations;fever, pale skin;urinating less than usual or not at all; orfeeling like you might pass out.


Less serious Generic Catapres (Clonidine) side effects may include:
feeling dizzy, drowsy, tired, or nervous;dry mouth;dry or burning eyes, blurred vision;headache, muscle or joint pain;nausea, vomiting, constipation, loss of appetite;sleep problems (insomnia);urinating more at night;mild skin rash or itching; ordecreased sex drive, impotence.


What other drugs will affect Generic Catapres (Clonidine)?
Before taking Generic Catapres (Clonidine), tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Generic Catapres (Clonidine).Tell your doctor about all other medications you use, especially:Generic Catapres (Clonidine) transdermal skin patches (Catapres TTS);digitalis (digoxin, Lanoxin, Lanoxicaps);an antidepressant such as amitriptyline (Elavil, Etrafon);a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;a calcium channel blocker such as amlodipine (Norvasc), diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nifedipine (Procardia, Adalat), verapamil (Calan, Covera, Isoptin, Verelan), and others; orany other drugs to treat high blood pressure or heart problems.This list is not complete and there may be other drugs that can interact with Generic Catapres (Clonidine). Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Generic Name Clonidine
Search Name Catapres Generic 100mcg TAB
Supply Name ARKAMIN
Brand Generic GENERIC
Presentation Foil in Pharmacy Box
Dosage TAB
USA Brand Catapres
Manufacture UNISEARCH
Strength 100mcg
Search Terms Catapres ,ARKAMIN ,Clonidine
Origin India

Use spaces to separate tags. Use single quotes (') for phrases.

FOR THE CONSUMER

Along with its needed effects, clonidine (the active ingredient contained in Catapres) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking clonidine:

Less common:
-Mental depression
-swelling of the feet and lower legs

Rare:
-Anxiety
-blistering, burning, crusting, dryness, or flaking of the skin
-chest pain or discomfort
-confusion as to time, place, or person
-decreased urine output
-dilated neck veins
-drowsiness
-dry mouth
-fast, pounding, or irregular heartbeat or pulse
-fever
-general feeling of discomfort or illness
-holding false beliefs that cannot be changed by fact
-hyperventilation
-irregular breathing
-irritability
-itching, scaling, severe redness, soreness, or swelling of the skin
-large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
-lightheadedness, dizziness, or fainting
-mental depression
-paleness or cold feeling in the fingertips and toes
-pounding, slow heartbeat
-problems in urination or increase in the amount of urine
-raised red swellings on the skin, lips, tongue, or in the throat
-restlessness
-seeing or hearing things that are not there
-shaking
-shortness of breath
-skin rash
-swelling of the face, fingers, feet, or lower legs
-tightness in the chest
-tingling or pain in the fingers or toes when exposed to cold
-trouble with sleeping
-troubled breathing
-unusual excitement, nervousness, or restlessness
-unusual tiredness or weakness
-vivid dreams or nightmares
-weight gain
-wheezing

Get emergency help immediately if any of the following symptoms of overdose occur while taking clonidine:

Symptoms of overdose:
-Dizziness (extreme) or faintness
-feeling cold
-pinpoint pupils of the eyes
-unusual tiredness or weakness (extreme)

Some side effects of clonidine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common:
-Constipation

Less common:
-Darkening of the skin
-decreased sexual ability
-dry, itching, or burning eyes
-loss of appetite
-nausea or vomiting

Rare:
-Blurred vision
-decreased interest in sexual intercourse
-hair loss or thinning of the hair
-inability to have or keep an erection
-leg cramps
-loss in sexual ability, desire, drive, or performance
-muscle or joint pain
-pale skin
-swelling of the breasts or breast soreness in both females and males
-weakness
USUAL ADULT DOSE FOR HYPERTENSION
Initial dose (PO): 0.1 mg orally twice a day (morning and bedtime).
Maintenance dose: 0.2 to 0.6 mg/day given in divided doses.
Initial dose (patches):Clonidine TTS-1 (0.1 mg/24 hr) applied once a week.
Maintenance dose: If after 1 to 2 weeks the desired reduction in blood pressure is not achieved, increase the dosage by adding another TTS-1 film or changing to a larger system.
An increase in dosage above 2 clonidine TTS-3 films is usually not associated with additional efficacy.
Extended-release tablets:
Initial dose: 0.17 mg orally once daily at bedtime. Further increments of 0.09 mg orally once daily may be made at weekly intervals if necessary until the desired response is achieved.
Maintenance dose: 0.17 mg to 0.52 mg orally once daily at bedtime
Extended-release oral suspension:
Initial dose: 0.17 mg (2 mL) orally once daily at bedtime. Further increments of 0.09 mg (1 mL) orally once daily may be made at weekly intervals if necessary until the desired response is achieved.
Maintenance dose: 0.17 mg to 0.52 mg orally once daily at bedtime

USUAL ADULT DOSE FOR PAIN
Continuous Epidural Infusion:
Initial dose: 30 mcg/hr.
May be titrated up or down depending on pain relief and occurrence of adverse events.
Maximum dose 40 mcg/hr.

USUAL ADULT DOSE FOR PHEOCHROMOCYTOMA DIAGNOSIS
0.3 mg orally once. Clonidine is only recommended after baseline determination of plasma catecholamines. Two baseline samples can be obtained five minutes apart from an existing IV line after the patient has remained supine for 90 minutes (a new needle stick could increase catecholamine concentrations and foul the test).
After the initial dose of clonidine, three additional hourly blood samples may be obtained for plasma catecholamine concentration measurements.
Generally, patients with hypertension and pheochromocytoma do NOT show a decrease in plasma catecholamine levels after this "suppression test", whereas hypertensive patients without pheochromocytoma do. False negative tests have been reported.

USUAL ADULT DOSE FOR HYPERTENSIVE EMERGENCY
0.2 mg orally once. Additional doses of 0.1 mg may be given as needed and tolerated every hour to control this patient's blood pressure. Be cognizant of the risk of stroke or heart attack or other problem associated with aggressive blood pressure reduction, especially in older persons. The maximum recommended total daily dose in any case of emergent hypertension is 0.8 mg.
Some clinicians report a poor antihypertensive effect of clonidine in patients with spinal injuries since this drug acts on the central nervous system to inhibit peripheral sympathetic tone, and the central and peripheral nervous systems are disrupted in these patients.

USUAL ADULT DOSE FOR ALCOHOL WITHDRAWAL
0.1 mg orally twice a day or TTS-1 (0.1 mg) transdermal patch once a week.

USUAL ADULT DOSE FOR ANXIETY
0.1 mg orally twice a day or TTS-1 (0.1 mg) transdermal patch once a week.

USUAL ADULT DOSE FOR BENZODIAZEPINE WITHDRAWAL
0.1 mg orally twice a day or TTS-1 (0.1 mg) transdermal patch once a week.

USUAL ADULT DOSE FOR MIGRAINE PROPHYLAXIS
0.1 mg orally twice a day or TTS-1 (0.1 mg) transdermal patch once a week.

USUAL ADULT DOSE FOR PERMIENOPAUSAL SYMPTOMS
0.1 mg orally twice a day or TTS-1 (0.1 mg) transdermal patch once a week.

USUAL ADULT DOSE FOR SMOKING CESSATION
0.1 mg orally twice a day or TTS-1 (0.1 mg) transdermal patch once a week.

USUAL ADULT DOSE FOR BIPOLAR DISORDER
0.1 mg orally twice a day or TTS-1 (0.1 mg) transdermal patch once a week.

USUAL ADULT DOSE FOR OPIATE WITHDRAWAL
0.2 mg orally twice a day or TTS-2 (0.2 mg) transdermal patch once a week.

USUAL PEDIATRIC DOSE FOR ATTENTION DEFICIT DISORDER
May be used alone or as an adjunct to stimulants.
Immediate release (unlabeled indication):
Children less than or equal to 45 kg:
Initial dose: 0.05 mg orally at bedtime. Increase sequentially every 3 to 7 days by 0.05 mg increments as 2 times daily, then 3 times daily, then 4 times daily.
Maximum dose: 0.2 mg/day orally for patients weighing 27 to 40.5 kg; 0.3 mg/day for patients weighing 40.5 to 45 kg.
When discontinuing therapy, taper gradually over 1 to 2 weeks.
Children greater than 45 kg:
Initial dose: 0.1 mg orally at bedtime. Increase sequentially every 3 to 7 days by 0.1 mg increments as 2 times daily, then 3 times daily, then 4 times daily
Maximum dose: 0.4 mg/day
When discontinuing therapy, taper gradually over 1 to 2 weeks.
Extended release (Kapva {R}):
Children greater than or equal to 6 years:
Initial dose: 0.1 mg orally at bedtime. Increase in 0.1 mg/day increments every 7 days until desired response. Doses should be administered twice daily (either split equally or with the higher split dosage given at bedtime).
Maximum dose: 0.4 mg/day orally
Note: Maintenance treatment for greater than 5 weeks has not been evaluated.
When discontinuing therapy, taper daily dose by less than or equal to 0.1 mg every 3 to 7 days.
Transdermal: Children may be switched to the transdermal delivery system after oral therapy is titrated to an optimal and stable dose; a transdermal dose approximately equivalent to the total oral daily dose may be used.
The dose of clonidine extended-release tablets, administered either as monotherapy or as adjunctive therapy to a psychostimulant, should be individualized according to the therapeutic needs and response of the patient. Dosing should be initiated with one 0.1 mg tablet at bedtime, and the daily dosage should be adjusted in increments of 0.1 mg/day at weekly intervals until the desired response is achieved. Doses should be taken twice a day, with either an equal or higher split dosage being given at bedtime.

RENAL DOSE ADJUSTMENTS
Doses should be titrated up slowly in patients with renal dysfunction.
CrCl less than 10 mL/min: The dose should be reduced by 50% to 75% of the normal initial dose.
For extended-release tablets and oral suspension: Adjust dosage according to the degree of impairment. In patients with end stage kidney disease on maintenance dialysis, start at 0.09 mg per day and titrate up slowly to minimize dose related adverse events.

DOSE ADJUSTMENTS
Elderly patients may benefit from a lower initial dose.
Dosing adjustments of 0.1 mg/day, may be made at weekly intervals if necessary until the desired response is achieved.
When switching from immediate-release to extended-release tablets:
Initial dose: Substitute 0.17 mg extended-release orally once daily for 0.1 mg immediate-release orally twice daily
Maintenance dose titration increments: Substitute 0.09 mg extended-release orally once daily for 0.05 mg immediate-release orally twice daily
Maintenance doses: Substitute 0.17 mg extended-release orally once daily for 0.1 mg immediate-release orally twice daily, or 0.34 mg extended-release orally once daily for 0.2 mg immediate-release orally twice daily, or 0.52 mg extended-release orally once daily for 0.3 mg immediate-release orally twice daily.
When switching from immediate-release tablets to extended-release oral suspension:
Initial dose: Substitute 0.17 mg (2 mL) extended-release orally once daily for 0.1 mg immediate-release orally twice daily
Maintenance dose titration increments: Substitute 0.09 mg (1 mL) extended-release orally once daily for 0.05 mg immediate-release orally twice daily
Maintenance doses: Substitute 0.17 mg (2 mL) extended-release orally once daily for 0.1 mg immediate-release orally twice daily, or 0.34 mg (4 mL) extended-release orally once daily for 0.2 mg immediate-release orally twice daily, or 0.52 mg (6 mL) extended-release orally once daily for 0.3 mg immediate-release orally twice daily.

PRECAUTIONS
When substituting clonidine topical film for oral clonidine or for other antihypertensive drugs, the antihypertensive effect of clonidine topical film may not commence until 2 to 3 days after initial application. Therefore, gradual reduction of prior drug dosage is advised. Some or all previous antihypertensive treatment may have to be continued, particularly in patients with more severe forms of hypertension.
Patients should not discontinue therapy without consulting a physician. Dose reduction should be performed gradually over a 2 to 4 day period to avoid withdrawal symptomatology. Rare instances of hypertensive encephalopathy, cerebrovascular accidents and death have been reported after clonidine withdrawal.
Patients with severe coronary insufficiency, conduction disturbances, recent myocardial infarction, cerebrovascular disease, or chronic renal failure should have their dosage titrated up slowly.
In perioperative use, clonidine extended-release tablets and suspension may be administered up to 28 hours prior to surgery and resumed the following day.
Clonidine extended-release tablet formulation is dosed twice a day, the same as the immediate-release clonidine formulation, but it is not to be used interchangeably with the immediate-release formulation.
Clonidine extended-release tablets must be swallowed whole and never crushed, cut or chewed.
Clonidine extended-release tablets may be taken with or without food.
Due to the lack of controlled clinical trial data and differing pharmacokinetic profiles, substitution clonidine extended-release tablets for other clonidine products on a mg-per-mg basis is not recommended.
Elderly patients may benefit from a lower initial dose of clonidine.
Safety and effectiveness of clonidine immediate-release, patches, extended-release tablets, and extended-release suspension have not been established in pediatric patients (less than 18 years of age). Safety and effectiveness of clonidine extended-release tablets have not been studied in children with ADHD less than 6 years old.

DIALYSIS
Since only a minimal amount of clonidine is removed during routine hemodialysis, there is no need to give supplemental clonidine following dialysis.

OTHER COMMENTS
Taking the larger portion of the oral daily dose at bedtime may minimize transient adjustment effects of dry mouth and drowsiness. In addition, administration at bedtime may minimize the risk of morning-associated cardiovascular events (i.e., stroke, transient ischemic attacks, myocardial infarction, or sudden cardiac death). Studies have indicated that 2.4 mg is the maximum effective daily dose, but doses as high as this have rarely been employed.
Apply clonidine topical film once every 7 days to a hairless area of intact skin on the upper outer arm or chest. Each new application of should be on a different skin site from the previous location. If the system loosens during 7-day wearing, the adhesive overlay should be applied directly over the system to ensure good adhesion. There have been rare reports of the need for patch changes prior to 7 days to maintain blood pressure control.
The effectiveness of clonidine extended-release tablets for longer-term use (more than 5 weeks) has not been systematically evaluated in controlled trials. Therefore the physician electing to use clonidine extended-release tablets for extended periods should periodically reevaluate the long-term usefulness of the drug for the individual patient.
When discontinuing clonidine extended-release tablets, the total daily dose should be tapered in decrements of no more than 0.1 mg every 3 to 7 days.