Neurontin 300mg (gabapentin) - Generic

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GABAPENTIN is the international generic and equivalent of Neurontin

Neurontin 300mg (gabapentin) - Generic

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What is Generic Neurontin (gabapentin)?
Generic Neurontin (gabapentin) is an anti-epileptic medication, also called an anticonvulsant. It affects chemicals and nerves in the body that are involved in the cause of seizures and some types of pain.Generic Neurontin (gabapentin) is used alone or in combination with other medications to treat seizures caused by epilepsy in adults and children who are at least 12 years old. Generic Neurontin (gabapentin) is also used with other medications to treat partial seizures in children who are 3 to 12 years old.Generic Neurontin (gabapentin) is also used to treat nerve pain caused by herpes virus or shingles.


Important information about Generic Neurontin (gabapentin)
You should not use Generic Neurontin (gabapentin) if you are allergic to gabapentin.Before taking Generic Neurontin (gabapentin), tell your doctor if you have kidney, liver, or heart disease.You may have thoughts about suicide while taking Generic Neurontin (gabapentin). Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.Do not stop taking Generic Neurontin (gabapentin) for seizures without first talking to your doctor, even if you feel better. You may have increased seizures if you stop taking Generic Neurontin (gabapentin) suddenly. You will need to use less and less before you stop the medication completely.Contact your doctor if your seizures get worse or you have them more often while taking Generic Neurontin (gabapentin).Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking a seizure medication.


Before taking Generic Neurontin (gabapentin)
You should not use Generic Neurontin (gabapentin) if you are allergic to gabapentin. If you have any of these other conditions, you may need a dose adjustment or special tests to safely take Generic Neurontin (gabapentin).kidney disease;liver disease; orheart disease.You may have thoughts about suicide while taking this medication. Tell your doctor if you have new or worsening depression or suicidal thoughts during the first several months of treatment, or whenever your dose is changed.Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.FDA pregnancy category C. It is not known whether Generic Neurontin (gabapentin) is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Generic Neurontin (gabapentin) can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.


How should I take Generic Neurontin (gabapentin)?
Take Generic Neurontin (gabapentin) exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.Generic Neurontin (gabapentin) can be taken with or without food.If you break a tablet and take one half of it, take the other half at your next dose. Any tablet that has been broken should be used as soon as possible or within a few days.Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.Generic Neurontin (gabapentin) can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using Generic Neurontin (gabapentin).Do not stop taking Generic Neurontin (gabapentin) for seizures without first talking to your doctor, even if you feel better. You may have increased seizures if you stop taking Generic Neurontin (gabapentin) suddenly. You will need to use less and less before you stop the medication completely. Contact your doctor if your seizures get worse or you have them more often while taking Generic Neurontin (gabapentin).Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking a seizure medication.It is important to use Generic Neurontin (gabapentin) regularly for best seizure control. Get your prescription refilled before you run out of medicine completely.


Store Generic Neurontin (gabapentin) tablets and capsules at room temperature away from light and moisture. Store the liquid medicine in the refrigerator. Do not freeze.


What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.


What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.Overdose symptoms may include blurred vision, drowsiness, weakness, slurred speech, or diarrhea.


What should I avoid while taking Generic Neurontin (gabapentin)?
Generic Neurontin (gabapentin) can cause side effects that may impair your vision or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.Avoid taking an antacid within 2 hours before or after you take Generic Neurontin (gabapentin). Antacids can make it harder for your body to absorb Generic Neurontin (gabapentin).


Side effects of Generic Neurontin (gabapentin) 
Get emergency medical help if you have any of these signs of an allergic reaction to Generic Neurontin (gabapentin): hives; fever; swollen glands; painful sores in or around your eyes or mouth; difficulty breathing; swelling of your face, lips, tongue, or throat.Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes,depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.Call your doctor at once if you have any of these serious side effects:increased seizures;fever, chills, body aches, flu symptoms;swelling of your ankles or feet;confusion;rapid back and forth movement of your eyes;tremor; oreasy bruising.Some side effects are more likely in children taking Generic Neurontin (gabapentin). Contact your doctor if the child taking this medication has any of the following side effects:changes in behavior;memory problems;trouble concentrating; oracting restless, hostile, or aggressive.


Less serious Generic Neurontin (gabapentin) side effects may include:
dizziness, drowsiness, weakness, tired feeling;lack of coordination;blurred vision;nausea, vomiting, stomach pain, loss of appetite;diarrhea, constipation;dry mouth;runny or stuffy nose, sore throat;headache;sleep problems (insomnia), unusual dreams; oracne, mild skin rash.This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. 


What other drugs will affect Generic Neurontin (gabapentin)?
The following drugs can interact with Generic Neurontin (gabapentin). Tell your doctor if you are using any of these:hydrocodone (Lortab, Vicodin, Vicoprofen, and others);morphine (Kadian, MS Contin, Oramorph, and others); ornaproxen (Naprosyn, Aleve, Anaprox, and others).This list is not complete and there may be other drugs that can interact with Generic Neurontin (gabapentin). Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Generic Name gabapentin
Search Name Neurontin Generic 300mg CAP
Supply Name GABAPENTIN
Brand Generic GENERIC
Presentation Foil in Box
Dosage CAP
USA Brand Neurontin
Manufacture UK GENERIC
Strength 300mg
Search Terms Neurontin,GABAPENTIN ,gabapentin
Origin UK

Use spaces to separate tags. Use single quotes (') for phrases.

For the Consumer

Applies to gabapentin: oral capsule, oral solution, oral suspension, oral tablet

Along with its needed effects, gabapentin (the active ingredient contained in Neurontin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking gabapentin:

More common
- Clumsiness or unsteadiness
- continuous, uncontrolled, back-and-forth, or rolling eye movements

More common in children
- Aggressive behavior or other behavior problems
- anxiety
- concentration problems and change in school performance
- crying
- depression
- false sense of well-being
- hyperactivity or increase in body movements
- rapidly changing moods
- reacting too quickly, too emotional, or overreacting
- restlessness
- suspiciousness or distrust

Less common
- Black, tarry stools
- chest pain
- chills
- cough
- depression, irritability, or other mood or mental changes
- fever
- loss of memory
- pain or swelling in the arms or legs
- painful or difficult urination
- shortness of breath
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swollen glands
- unusual bleeding or bruising
- unusual tiredness or weakness

Incidence not known
- Abdominal or stomach pain
- blistering, peeling, or loosening of the skin
- clay-colored stools
- coma
- confusion
- convulsions
- dark urine
- decreased urine output
- diarrhea
- dizziness
- fast or irregular heartbeat
- headache
- increased thirst
- itching
- joint pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- muscle ache or pain
- nausea
- red skin lesions, often with a purple center
- red, irritated eyes
- skin rash
- unpleasant breath odor
- vomiting of blood
- yellow eyes or skin

Some side effects of gabapentin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
- Blurred vision
- cold or flu-like symptoms
- delusions
- dementia
- hoarseness
- lack or loss of strength
- lower back or side pain
- swelling of the hands, feet, or lower legs
- trembling or shaking

Less common or rare
- Accidental injury
- appetite increased
- back pain
- bloated or full feeling
- body aches or pain
- burning, dry, or itching eyes
- change in vision
- change in walking and balance
- clumsiness or unsteadiness
- congestion
- constipation
- cough producing mucus
- decrease in sexual desire or ability
- dementia
- difficulty with breathing
- dryness of the mouth or throat
- earache
- excess air or gas in the stomach or intestines
- excessive tearing
- eye discharge
- feeling faint, dizzy, or lightheadedness
- feeling of warmth or heat
- flushed, dry skin
- flushing or redness of the skin, especially on the face and neck
- frequent urination
- fruit-like breath odor
- impaired vision
- incoordination
- increased hunger
- increased sensitivity to pain
- increased sensitivity to touch
- increased thirst
- indigestion
- low blood pressure
- nervousness
- noise in the ears
- pain, redness, rash, swelling, or bleeding where the skin is rubbed off
- passing gas
- redness or swelling in the ear
- redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
- runny nose
- sneezing
- sweating
- tender, swollen glands in the neck
- tightness in the chest
- tingling in the hands and feet
- troubled breathing
- trouble with sleeping
- trouble with swallowing
- trouble with thinking
- twitching
- unexplained weight loss
- voice changes
- vomiting
- weakness or loss of strength
- weight gain
- wheezing
USUAL ADULT DOSE FOR EPILEPSY

Initial dose: 300 mg orally on day one, 300 mg orally twice a day on day two, then 300 mg orally 3 times a day on day three.
Maintenance dose: 900 to 1800 mg orally in 3 divided doses. If necessary, the dose may be increased using 300 mg or 400 mg capsules three times a day up to 1800 mg/day. Dosages up to 2400 mg/day have been well tolerated in long-term clinical studies. Doses of 3600 mg/day have also been administered to a small number of patients for a relatively short duration, and have been well tolerated. The maximum time between doses in the three times a day schedule should not exceed 12 hours.

The safety and effectiveness of gabapentin available under the trade name Gralise (R) or Horizant (R) in patients with epilepsy has not been studied.

USUAL ADULT DOSE FOR POSTHERPETIC NEURALGIA

Initial dose: 300 mg orally on day one, 300 mg orally twice a day on day two, then 300 mg orally 3 times a day on day three.

The dose may be titrated up as needed for pain relief to a daily dose of 1800 mg.
Maintenance dose: 900 to 1800 mg orally in 3 divided doses.

Efficacy was demonstrated in clinical studies over a range of 1800 mg/day to 3600 mg/day. However, no additional benefit was demonstrated from the use of doses over 1800 mg/day.

Gabapentin available under the trade name Gralise (R):

Maintenance dose: Gralise (R) should be titrated to 1800 mg orally once daily with the evening meal.

Recommended titration schedule:
Day 1: 300 mg orally with the evening meal
Day 2: 600 mg orally with the evening meal
Days 3 through 6: 900 mg orally with the evening meal
Days 7 through 10: 1200 mg orally with the evening meal
Days 11 through 14: 1500 mg orally with the evening meal
Day 15: 1800 mg orally with the evening meal

Gralise (R) is not interchangeable with other gabapentin products because of differing pharmacokinetic profiles that affect the frequency of administration.

Gabapentin enacarbil extended release tablets available under the trade name Horizant (R):

The recommended dosage is 600 mg orally twice daily. Therapy should be initiated at a dose of 600 mg orally in the morning for 3 days of therapy, then increased to 600 mg twice daily (1,200 mg/day) on day four.

Gabapentin enacarbil extended release tablets available under the trade name Horizant (R) and gabapentin are not interchangeable.

USUAL ADULT DOSE FOR RESTLESS LEGS SYNDROME

Gabapentin enacarbil available under the trade name Horizant (R):
600 mg orally once daily with food at about 5 PM

USUAL PEDIATRIC DOSE FOR EPILEPSY

Less than 3 years: Effectiveness has not been established.

Greater than or equal to 3 and less than 12 years:
Starting Dose: ranges from 10 to 15 mg/kg/day in 3 divided doses.
Effective Dose: reached by upward titration over a period of approximately 3 days. The effective dose of gabapentin in patients 5 years of age and older is 25 to 35 mg/kg/day and given in divided doses (three times a day). The effective dose in pediatric patients ages 3 and 4 years is 40 mg/kg/day and given in divided doses (three times a day). Gabapentin may be administered as the oral solution, capsule, or tablet, or using combinations of these formulations. Dosages up to 50 mg/kg/day have been well tolerated in a long term clinical study. The maximum time interval between doses should not exceed 12 hours.

Greater than 2 years:
Initial dose: 300 mg orally on day one, 300 mg orally twice a day on day two, then 300 mg orally 3 times a day on day three.
Maintenance dose: 900 to 1800 mg orally in 3 divided doses. If necessary, the dose may be increased using 300 mg or 400 mg capsules three times a day up to 1800 mg/day. Dosages up to 2400 mg/day have been well tolerated in long term clinical studies. Doses of 3600 mg/day have also been administered to a small number of patients for a relatively short duration, and have been well tolerated. The maximum time between doses in the three times a day schedule should not exceed 12 hours.

RENAL DOSE ADJUSTMENTS

For patients greater than or equal to 12 years:
CrCl less than 15 mL/min: 300 mg orally every other day
CrCl 15 to 30 mL/min: 300 mg orally once a day
CrCl 30 to 60 mL/min: 300 mg orally twice a day
CrCl greater than 60 mL/min: 400 mg orally 3 times a day

The dose of gabapentin available under the trade name Gralise (R) should be adjusted in patients with reduced renal function. Patients with reduced renal function should initiate Gralise (R) at a daily dose of 300 mg. Daily dosing in patients with reduced renal function should be individualized based on tolerability and desired clinical benefit. Gralise (R) should be titrated following the schedule outlined below:
CrCl less than 30 mL/min: Gralise (R) should not be administered
CrCl 30 to 60 mL/min: 600 to 1800 mg orally with the evening meal
CrCl greater than or equal to 60 mL/min: 1800 mg orally with the evening meal

The dose of gabapentin enacarbil available under the trade name Horizant (R) should be adjusted in patients with reduced renal function as follows:

Restless Legs Syndrome:
CrCl greater than or equal to 60 ml/min: 600 mg orally once a day
CrCl 30 to 59 ml/min: Start at 300 mg orally daily and increase to 600 mg as needed
CrCl 15 to 29 ml/min: 300 mg orally once a day
CrCl less than 15 ml/min: 300 mg orally every other day
CrCl less than 15 ml/min on dialysis: not recommended

Postherpetic Neuralgia:
CrCl greater than or equal to 60 ml/min: 600 mg orally in the morning for 3 days, then 600 mg twice a day thereafter.
CrCl 30 to 59 ml/min: 300 mg orally in the morning for 3 days, then 300 mg twice a day thereafter. Increase to 600 mg twice daily as needed based on tolerability and efficacy.
CrCl 15 to 29 ml/min: 300 mg orally in the morning on day 1 and day 3 of therapy, then 300 mg once a day in the morning. May increase to 300 mg twice daily if needed based on tolerability and efficacy.
CrCl less than 15 ml/min: 300 mg orally every other day in the morning. May increase to 300 mg once daily in the morning if needed based on tolerability and efficacy.
CrCl less than 15 ml/min on dialysis: 300 mg orally following every dialysis. May increase to 600 mg following every dialysis if needed based on efficacy and tolerability.

LIVER DOSE ADJUSTMENTS

Data not available

DOSE ADJUSTMENTS

If the dose of gabapentin available under the trade name Gralise (R) is reduced, discontinued, or substituted with an alternative medication, this should be done gradually over a minimum of one week or longer or as directed by the physician.

If the dose of gabapentin enacarbil available under the trade name Horizant (R) is discontinued, patients with RLS receiving 600 mg or less once daily can discontinue the drug without tapering. Patients with PHN receiving Horizant (R) twice daily should reduce the dose to once daily for 1 week prior to discontinuation to minimize the potential for withdrawal seizure.

PRECAUTIONS

If gabapentin is discontinued and/or an alternate anticonvulsant medication is added to the therapy, this should be done gradually over a minimum of 1 week.

The safety and effectiveness of gabapentin available under the trade names Gralise (R) or Horizant (R) in patients with epilepsy has not been studied.

Gabapentin available under the trade names Gralise (R) or Horizant (R) are not interchangeable with each other or with other gabapentin products.

Gabapentin available under the trade name Gralise (R) should be titrated to the maintenance dose.

Gabapentin available under the trade names Gralise (R) or Horizant (R) tablets should be swallowed whole, not crushed, split, or chewed.

If the dose of gabapentin available under the trade name Gralise (R) is reduced, discontinued, or substituted with an alternative medication, this should be done gradually over a minimum of one week or longer or as directed by the physician.

An antacid containing aluminum hydroxide and magnesium hydroxide reduced the bioavailability of gabapentin immediate release by about approximately 20%, but by only 5% when gabapentin was taken 2 hours after antacids. It is recommended that gabapentin available under the trade name Gralise (R) be taken at least 2 hours following antacid administration.

Safety and effectiveness of gabapentin available under the trade names Gralise (R) or Horizant (R) have not been established in pediatric patients (less than 18 years of age).

DIALYSIS

A 200 to 300 mg dose should be administered following dialysis.

Gabapentin available under the trade name Gralise (R) is contraindicated in patients receiving dialysis.

Gabapentin enacarbil available under the trade name Horizant (R):
RLS:
CrCl less than 15 ml/min on dialysis: Not recommended
PHN:
CrCl less than 15 ml/min on dialysis: 300 mg orally following every dialysis. May increase to 600 mg following every dialysis if needed based on tolerability and efficacy.

OTHER COMMENTS

Gabapentin may be given with or without food. Gabapentin enacarbil available under the trade name Horizant (R) should be taken with food.

Gabapentin available under the trade name Gralise (R) should be taken once daily with the evening meal.

Gabapentin enacarbil available under the trade name Horizant (R) should be swallowed whole and should not be cut, crushed, or chewed. For RLS, a daily dose of 1,200 mg provided no additional benefit compared with the 600 mg dose, but caused an increase in adverse reactions. For PHN, a daily dose greater than 1,200 mg conferred no additional benefit and resulted in an increase in adverse reactions.

If the dose of Horizant (R) is not taken at the recommended time, it should be skipped, and the next dose should be taken at the time of the next scheduled dose.