Aredia 90mg (Pamidronate Disodium) - Generic

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PAMIDRO INJ. is the international generic and equivalent of Aredia

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Aredia 90mg  (Pamidronate Disodium) - Generic

What is Generic Aredia (Pamidronate Disodium)?
Pamidronate is in a group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation and breakdown in the body.Pamidronate is used to treat high levels of calcium in the blood related to cancer (also called hypercalcemia of malignancy). Pamidronate is also used to treat Paget's disease of bone.Pamidronate is used to treat bone damage caused by certain types of cancer such as breast cancer or bone marrow cancer. Pamidronate does not treat cancer. Use all other medications your doctor has prescribed for those conditions.Pamidronate may also be used for purposes not listed in this medication guide.


What is the most important information I should know about Generic Aredia (Pamidronate Disodium)?
Do not use pamidronate if you are pregnant. It could harm the unborn baby. You should not use this medication if you are allergic to pamidronate or to other bisphosphonates such as alendronate (Fosamax), etidronate (Didronel), ibandronate (Boniva), risedronate (Actonel), tiludronate (Skelid), or zoledronic acid (Reclast, Zometa). Before using pamidronate, tell your doctor if you have kidney disease, a history of thyroid surgery, or low levels of platelets or red blood cells.Some people using medicines similar to pamidronate have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem.Pamidronate can harm your kidneys, and this effect is increased when you also use certain other medicines harmful to the kidneys. Before using pamidronate, tell your doctor about all other medications you use. Many other drugs (including some over-the-counter medicines) can be harmful to the kidneys.Serious side effects of pamidronate include high fever, severe bone pain, severe joint or muscle pain, urinating less than usual or not at all, swelling, rapid weight gain, eye pain, vision changes, confusion, uneven heart rate, extreme thirst, muscle weakness or limp feeling, or seizure. 


What should I discuss with my healthcare provider before using Generic Aredia (Pamidronate Disodium)?
You should not use this medication if you are allergic to pamidronate or to other bisphosphonates such as alendronate (Fosamax), etidronate (Didronel), ibandronate (Boniva), risedronate (Actonel), tiludronate (Skelid), or zoledronic acid (Reclast, Zometa). To make sure you can safely use pamidronate, tell your doctor if you have any of these other conditions:kidney disease;a history of thyroid surgery; orlow levels of platelets or red blood cells.Some people using medicines similar to pamidronate have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms of this condition may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums.You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and dental surgery or pre-existing dental problems.FDA pregnancy category D. Do not use pamidronate if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether pamidronate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. 


How is pamidronate given?
Pamidronate is injected into a vein through an IV. This medication must be given slowly, and the IV infusion can take up 2 to 24 hours to complete. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.Pamidronate is sometimes given as a single dose only one time. It may also be repeated over 3 days in a row, or given once every 3 to 4 weeks. How often you receive this medication and the length of your infusion time will depend on the condition being treated. Follow your doctor's instructions.You may need to mix pamidronate with a liquid (diluent) in an IV bag before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication. Never mix pamidronate with a solution that contains calcium (such as lactated Ringer's solution) or with other drugs in the same IV bag or line.Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.If you do not have hypercalcemia, your doctor may want you to take calcium or vitamin D supplements by mouth while you are using pamidronate. Do not take any vitamin or mineral supplements that your doctor has not prescribed. To be sure this medicine is helping your condition and is not causing harmful effects, your blood will need to be tested often. Visit your doctor regularly. Store unmixed pamidronate at room temperature away from moisture and heat. After mixing pamidronate with a diluent, store in the refrigerator and use it within 24 hours. Do not freeze. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription. 


What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of pamidronate.


What happens if I overdose?
Seek emergency medical attention or call the Poison Help line. 


What should I avoid while using Generic Aredia (Pamidronate Disodium)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.


Side effects of Generic Aredia (Pamidronate Disodium)  
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as: high fever;severe joint, bone, or muscle pain;urinating less than usual or not at all;swelling, rapid weight gain;pain or burning when you urinate;seizure (convulsions);eye pain, vision changes;pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; orconfusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling, or jerking muscle movements.


Less serious side effects may include:
low fever;stomach pain, loss of appetite, nausea, vomiting;constipation; orpain, redness, swelling or a hard painful lump under your skin around the IV needle.This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. 


What other drugs will affect Generic Aredia (Pamidronate Disodium)?
Pamidronate can harm your kidneys. This effect is increased when you also use other medicines harmful to the kidneys. You may need dose adjustments or special tests if you have recently used:lithium (Lithobid);methotrexate (Rheumatrex, Trexall);pain or arthritis medicines such as aspirin (Anacin, Excedrin), acetaminophen (Tylenol), diclofenac (Cataflam, Voltaren), etodolac (Lodine), ibuprofen (Advil, Motrin), indomethacin (Indocin), naproxen (Aleve, Naprosyn), and others;medicines used to treat ulcerative colitis, such as mesalamine (Pentasa) or sulfasalazine (Azulfidine);medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) or tacrolimus (Prograf);IV antibiotics such as amphotericin B (Fungizone, AmBisome, Amphotec, Abelcet), amikacin (Amikin), bacitracin (Baci-IM), capreomycin (Capastat), gentamicin (Garamycin), kanamycin (Kantrex), streptomycin, or vancomycin (Vancocin, Vancoled);antiviral medicines such as adefovir (Hepsera), cidofovir (Vistide), or foscarnet (Foscavir); orcancer medicine such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), streptozocin (Zanosar), or tretinoin (Vesanoid).This list is not complete and other drugs may interact with pamidronate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Generic Name Pamidronate Disodium
Search Name Aredia Generic 90mg unit
Supply Name PAMIDRO INJ.
Brand Generic GENERIC
Presentation vial in Box
Dosage unit
USA Brand Aredia
Manufacture NEW MEDICON
Strength 90mg
Search Terms Aredia ,PAMIDRO INJ. ,Pamidronate Disodium
Origin India

Use spaces to separate tags. Use single quotes (') for phrases.

FOR THE CONSUMER

Along with its needed effects, pamidronate (the active ingredient contained in Aredia) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pamidronate:

More common:
-Abdominal or stomach cramps
-black, tarry stools
-bloody in the urine or stools
-blurred vision
-chest pain
-chills
-confusion
-convulsions (seizures)
-decrease in the amount of urine
-dizziness
-drowsiness
-fainting
-fast or irregular heartbeat
-fever
-headache
-increased thirst
-loss of appetite
-muscle pain, cramps, spasms, or twitching
-nausea or vomiting
-nervousness
-noisy, rattling breathing
-numbness or tingling in the hands, feet, or lips
-pinpoint red spots on the skin
-pounding in the ears
-shortness of breath
-slow or fast heartbeat
-swelling of the fingers, hands, feet, or lower legs
-trembling
-troubled breathing at rest
-unusual bleeding or bruising
-unusual tiredness or weakness
-vomiting of blood or material that looks like coffee grounds
-weight gain

Less common:
-Cough
-dilated neck veins
-extreme fatigue
-irregular breathing
-lower back or side pain
-painful or difficult urination
-pale skin
-swelling
-ulcers, sores, or white spots in the mouth

Rare:
-Decreased vision
-difficulty with swallowing
-eye pain or tenderness
-eye redness
-hives
-itching
-large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
-sensitivity of the eye to light
-skin rash
-sweating
-tearing of the eye
-tightness in the chest

Incidence not known:
-Bone, joint, or muscle pain, severe and occasionally incapacitating
-faintness, or lightheadedness when getting up suddenly from a lying or sitting position

Some side effects of pamidronate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common:
-Acid or sour stomach
-belching
-bladder pain
-bloody or cloudy urine
-body aches or pain
-bone pain
-constipation
-cracks in the skin at the corners of mouth
-diarrhea
-difficult, burning, or painful urination
-difficult or labored breathing
-difficulty moving
-ear congestion
-fear
-frequent urge to urinate
-heartburn
-indigestion
-joint pain
-lack or loss of strength
-lower back or side pain
-muscle aching, cramping, pains, or stiffness
-nasal congestion
-nervousness
-pain and swelling at the injection site
-sensitivity to heat
-shivering
-sneezing
-soreness or redness around the fingernails and toenails
-stomach discomfort, upset, or pain
-sweating
-swollen joints
-trouble sleeping
-weight loss

Less common:
-Ammonia-like breath odor
-feeling, seeing, or hearing things that are not there
-feeling that others are watching you or controlling your behavior
-feeling that others can hear your thoughts
-feeling unusually cold
-swelling or inflammation of the mouth
-unusual behavior
USUAL ADULT DOSE FOR HYPERCALCEMIA OF MALIGNANCY
60 to 90 mg as a single dose, intravenously by slow infusion over 2 to 24 hours one time. Longer infusions (i.e., > 2 hours) may reduce the risk for renal toxicity, particularly in patients with preexisting renal insufficiency. If significant hypercalcemia persists or recurs, a second dose, identical to the first, may be considered. A minimum of 7 days should elapse between doses. Response to subsequent doses may be diminished. Patients with frequent recurrences of hypercalcemia may require infusions of pamidronate every 2 to 3 weeks to maintain normocalcemia.

USUAL ADULT DOSE FOR PAGET'S DISEASE
30 mg intravenously as a 4 hour infusion on 3 consecutive days. A limited number of patients have received more than one treatment with the same dosage.

USUAL ADULT DOSE FOR OSTEOLYTIC BONE LESIONS OF MULTIPLE MYELOMA
90 mg intravenously as a 4 hour infusion given on a monthly basis for up to 9 months.

USUAL ADULT DOSE FOR OSTEOLYTIC BONE METASTASES OF BREAST CANCER
90 mg intravenously as a 2 hour infusion given every 3 to 4 weeks.

USUAL PEDIATRIC DOSE FOR HYPERCALCEMIA
> 1 year:
0.5 to 1 mg/kg intravenously by slow infusion over 24 hours one time. If significant hypercalcemia persists or recurs, a second dose, identical to the first, may be considered. A minimum of 7 days should elapse between doses.

OTHER COMMENTS
Because pamidronate is associated with hypophosphatemia, hypokalemia, hypocalcemia, and hypomagnesemia, careful monitoring of calcium, potassium, phosphate, and magnesium is recommended.