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Neksium (Esomeprazole) 40 mg

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Neksium is manufactured by AstraZeneca
Price From: $30.00

Neksium (Esomeprazole) 40 mg

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What is Neksium (Esomeprazole)?

This Medication contains esomeprazole,decreases the amount of acid produced in the stomach. This is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. It is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).It may also be given to prevent gastric ulcer caused by infection with helicobacter pylori (H. pylori), or by the use of nonsteroidal anti-inflammatory drugs (NSAIDs).This medicine is not for immediate relief of heartburn symptoms.It may also be used for other purposes not listed in this medication guide.


Important information-


 You should not take this medication, if you are allergic to esomeprazole or to any other benzimidazole medication such as albendazole (Albenza), or mebendazole (Vermox).If you have severe liver disease you may need an it dose adjustment or special tests.It is not for immediate relief of heartburn symptoms.Some conditions are treated with a combination of it and antibiotics. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.Take it for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Do not crush, chew, break, or open a delayed-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.


Before taking the medication-


 You should not take it, if you are allergic to esomeprazole or to any other benzimidazole medication such as albendazole (Albenza), or mebendazole (Vermox).If you have severe liver disease you may need an it dose adjustment or special tests.Some conditions are treated with a combination of it and antibiotics. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.


How should I take this medication?


Take it exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.It is usually given for 4 to 8 weeks only. Your doctor may recommend a second course of treatment if you need additional healing time.Take each dose with a full glass (8 ounces) of water. It should be taken at least one hour before a meal. Do not crush, chew, break, or open a delayed-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.You may open the delayed-release capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow this mixture right away without chewing. Do not save the mixture for later use. Discard the empty capsule.It can be given through a nasogastric (NG) feeding tube. Open the capsule and sprinkle the medicine into a 60-milliliter syringe. Mix in 50 milliliters of water. Place the plunger into the syringe and shake the mixture well. Make sure there are no medicine granules stuck in the tip of the syringe. Attach the syringe to the NG tube and push the plunger down to empty the syringe into the tube. Then flush the tube with more water to wash the contents down.Use it regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.Take it for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.


Store at room temperature away from moisture and heat.


What happens if I miss a dose?


Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention.
Overdose symptoms may include confusion, headache, drowsiness, blurred vision, fast heartbeat, nausea, dry mouth, sweating, flushing, shortness of breath, tremor, loss of coordination, or seizure (convulsions).


What should I avoid while taking it?


Follow your doctor's instructions about any restrictions on food, beverages, or activity.


Side effects-


Get emergency medical help if you have any of these signs of an allergic reaction to it: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.Less serious it side effects may include:headache;diarrhea;nausea, stomach pain, gas, constipation; ordry mouth.


What other drugs will affect it?


Tell your doctor about all other medicines you use, especially:a blood thinner such as warfarin (Coumadin);cilostazol (Pletal);clopidogrel (Plavix);digoxin (Lanoxin, Lanoxicaps);diazepam (Valium);ketoconazole (Extina, Ketozole, Nizoral, Xolegal);HIV or AIDS medication such as atazanavir (Reyataz), nelfinavir (Viracept), saquinavir (Invirase), and others; oriron (Feosol, Mol-Iron, Fergon, Femiron, others).





Generic Name Esomeprazole
Search Name Nexium Brand 40 mg TAB
Supply Name Neksium
Brand Generic BRAND NAME
Presentation Foil in Box
Dosage TAB
USA Brand Nexium
Manufacture AstraZeneca India Pvt. Ltd.
Strength 40 mg
Search Terms Nexium ,Neksium ,Esomeprazole
Origin India

Use spaces to separate tags. Use single quotes (') for phrases.

For the Consumer

Applies to esomeprazole: oral capsule delayed release, oral packet

Other dosage forms:

intravenous powder for solution
Along with its needed effects, esomeprazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking esomeprazole:

Incidence not known
- Blistering, peeling, or loosening of the skin
- bloating
- chills
- constipation
- cough
- darkened urine
- difficulty with swallowing
- dizziness
- drowsiness
- fast heartbeat
- fever
- hives
- indigestion
- itching
- joint or muscle pain
- loss of appetite
- mood or mental changes
- muscle spasms (tetany) or twitching
- nausea
- pains in the stomach, side, or abdomen, possibly radiating to the back
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red, irritated eyes
- red skin lesions, often with a purple center
- seizures
- shortness of breath
- skin rash
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips
- tightness in the chest
- trembling
- unusual tiredness or weakness
- vomiting
- wheezing
- yellow eyes or skin

Some side effects of esomeprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
- Bad, unusual, or unpleasant (after) taste
- change in taste

Less common
- Sleepiness or unusual drowsiness

Rare
- Acne
- back pain

Incidence not known
- Agitation
- dry mouth
- excess air or gas in the stomach or intestines
- full feeling
- hair loss or thinning of the hair
- muscular weakness
- passing gas
- seeing, hearing, or feeling things that are not there
- swelling of the breasts or breast soreness in both females and males
- swelling or inflammation of the mouth
- swollen joints
USUAL ADULT DOSE FOR GASTROESOPHAGEAL REFLUX DISEASE

20 mg orally once a day for 4 to 8 weeks. It may be administered by the intravenous route if unable to use oral route.

USUAL ADULT DOSE FOR EROSIVE ESOPHAGITIS

Healing: 20 to 40 mg orally once a day for 4 to 8 weeks. An additional 4 to 8 week course of therapy may be considered in patients not healed after initial treatment. It may be administered by the intravenous route if unable to use oral route.

Maintenance of healing: 20 mg orally once daily, for up to 6 months.

USUAL ADULT DOSE FOR HELICOBACTER PYLORI INFECTION

40 mg orally once a day for 10 days along with amoxicillin 1000 mg and clarithromycin 500 mg orally twice a day for 10 days.

USUAL ADULT DOSE FOR NSAID-INDUCED GASTRIC ULCER

20 to 40 mg orally once daily for up to 6 months.

USUAL ADULT DOSE FOR ZOLLINGER-ELLISON SYNDROME

40 mg orally twice daily. Doses up to 240 mg daily have been used.

USUAL ADULT DOSE FOR PATHOLOGICAL HYPERSECRETORY CONDITIONS

40 mg orally twice daily. Doses up to 240 mg daily have been used.

USUAL PEDIATRIC DOSE FOR GASTROESOPHAGEAL REFLUX DISEASE

12 to 17 year olds: 20 mg once daily
Duration of therapy: 4 weeks

1 to 11 year olds: 10 mg once daily
Duration of therapy: For up to 8 weeks
Comments: Doses over 1 mg/kg/day have not been studied.

USUAL PEDIATRIC DOSE FOR EROSIVE ESOPHAGITIS

Healing:
12 to 17 year olds: 20 or 40 mg once daily
Duration of therapy: 4 to 8 weeks
1 to 11 year olds:
-weight less than 20 kg: 10 mg once daily
-weight greater than or equal to 20 kg: 10 or 20 mg once daily
Duration of therapy: 8 weeks
Comments: Doses over 1 mg/kg/day have not been studied.

Due to acid-mediated GERD:
1 month to less than 1 year old:
-weight 3 kg to 5 kg: 2.5 mg once daily
-weight greater than 5 kg to 7.5 kg: 5 mg once daily
-weight greater than 7.5 kg to 12 kg: 10 mg once daily
Duration of therapy: For up to 6 weeks
Comments: Doses over 1.33 mg/kg/day have not been studied.

When oral therapy is not possible or appropriate (GERD with Erosive Esophagitis):
1 month to less than 1 year of age: 0.5 mg/kg once daily IV infusion over 10 minutes to 30 minutes
1 year to 17 years:
-weight less than 55 kg: 10 mg once daily IV infusion over 10 minutes to 30 minutes
-weight 55 kg or greater: 20 mg once daily IV infusion over 10 minutes to 30 minutes

RENAL DOSE ADJUSTMENTS

No adjustments recommended

LIVER DOSE ADJUSTMENTS

No dosage adjustment is recommended for patients with mild to moderate hepatic insufficiency (Child-Pugh class A and B). In patients with severe hepatic insufficiency (Child-Pugh class C), the maximum daily dose should not exceed 20 mg.

PRECAUTIONS

Consult WARNINGS section for dosing related precautions.

DIALYSIS

Not dialyzable

OTHER COMMENTS

Administration advice:
Oral Capsules:
-Take at least one hour before meals.
-Delayed-release capsule can be opened and mixed with 1 tablespoon of applesauce and swallowed immediately. Any unused mixture should be discarded. Mixing with other foods has not been evaluated and is not recommended.
Intravenous:
-The intravenous injection of esomeprazole should be administered over no less than 3 minutes. The intravenous infusion should be administered over 10 to 30 minutes.
-Treatment with esomeprazole injection is intended for short-term treatment (up to 10 days).

Storage requirements: Keep the delayed-release capsules in a tightly closed container.

Reconstitution/preparation techniques:
Delayed-release capsule:
-For patients with a nasogastric tube (NG), the delayed-release capsule can be opened, emptied into a 60 mL catheter tipped syringe, and mixed with 50 mL of water. Shake for 15 seconds, check for granules remaining in the tip, deliver contents through the NG tube, and flush the NG tube with water. Use mixture immediately after preparing. Rinse syringe with water after each use.
Oral suspension:
-Oral administration: Empty contents of 2.5 mg or 5 mg packet into 5 mL of water. Use 15 mL of water for the 10 mg, 20 mg and 40 mg packets. Stir, let thicken for 2 to 3 minutes, stir again, and drink within 30 minutes. Mix any remaining medicine with more water, stir, and drink.
-Nasogastric (NG) or gastric tube: Add 5 mL water to a catheter tipped syringe and add contents of a 2.5 mg or 5 mg packet. Use 10 mL water for the 10 mg, 20 mg and 40 mg packets. Shake the syringe and let thicken for 2 to 3 minutes. Shake syringe prior to injecting through the NG or gastric tube using a French size 6 or larger. Use mixture within 30 minutes. Refill the syringe with equal amount of water originally used, shake, and flush any remaining contents from NG or gastric tube.

Patient advice:
-Do not chew or crush capsules.
-Antacids can be used during treatment.